Exercise mimetics, colloquially known as “exercise pills,” have become a focal point in research. These substances aim to activate chemical pathways similar to those stimulated by physical exercise. The overarching idea is to develop drugs or supplements that replicate the benefits of exercise without the need for actual physical activity, offering a promising alternative for fitness and health.
Among the various exercise mimetics, a noteworthy category is the AMPK activators. AMPK (adenosine monophosphate-activated protein kinase) is a crucial metabolic sensor activated during exercise. It enhances insulin sensitivity, boosts mitochondrial energy production, and plays a role in skeletal muscle metabolism. Some potent AMPK activators are derived from plants, specifically polyphenols, such as resveratrol and cyanidin 3-glucoside.
Research has shown that these polyphenols, particularly resveratrol and cyanidin 3-glucoside, have exercise-mimetic effects. In a study involving young rats, different groups were subjected to high-calorie diets with added fat. Those that also consumed polyphenol-rich grape juice demonstrated improved insulin sensitivity, skeletal muscle insulin sensitivity, and exercise capacity. The synergistic effect of exercise and polyphenol intake resulted in enhanced body composition, replacing fatty deposits in the liver with glycogen.
The recommended dose in the study was 32-33 mg/kg/day of polyphenol-rich grape juice, containing less resveratrol or cyanidin 3-glucoside than a human would find in one capsule of either supplement. Another study focusing on cyanidin 3-glucoside found that it not only improved endurance but also increased muscle weight and protein content, along with a significant rise in mitochondrial population for greater energy production in cells.
While the idea of “exercise pills” is intriguing, the study emphasizes the importance of combining exercise with specific polyphenols. Resveratrol and cyanidin 3-glycoside, available as supplements like Rez-V and Indigo-3G, respectively, showcase synergistic effects with exercise. These polyphenols are recognized for their various health benefits, including fat burning, increased insulin sensitivity, and improved endurance, contributing to overall fitness and well-being.
